Jyothsna Gattineni, M.D., FAAP, and Michael A. Levine, M.D., FAAP, will present “Treatment
of Vitamin D Deficiency (S1125)” from 4-5:30 p.m. Saturday, Nov. 3 in room W311CD
of the convention center.
Dr. Gattineni is a member of the AAP Section on Nephrology and associate professor
of pediatrics at University of Texas Southwestern Medical Center. Dr. Levine is director
of the Center for Bone Health at Children's Hospital of Philadelphia.
In the following Q&A, Dr. Gattineni summarizes what they plan to discuss during the
seminar and why this session is important for pediatricians.
Q: What are the key things you will be covering during the session?
A: We will be discussing the physiology and regulation of vitamin D; the prevalence
of vitamin D deficiency in children, including nutritional rickets; and risk factors
for vitamin D deficiency in children.
We also will discuss treatment options for vitamin D deficiency; the side effects
of overtreating children with vitamin D, including increased risk of hypercalcemia
and kidney stones in certain groups of children; the role of vitamin D in patients
with chronic kidney disease; and effects of vitamin D in extraskeletal organs especially
the immune system.
Q: Why should pediatricians attend this session?
A: Pediatricians are on the front line to identify and treat children with vitamin
D deficiency. Thus, it will be useful for pediatricians to understand the physiology
and vitamin D homeostasis and how to manage vitamin D deficiency while avoiding complications
of vitamin D excess.
Q: How did you get interested in vitamin D deficiency?
A: I got interested in vitamin D deficiency due to my exposure to a patient with rickets
during my fellowship. In addition, during my fellowship, my research was focused on
identifying the receptors that fibroblast growth factor 23 binds to in the kidney
to regulate vitamin D homeostasis. Fibroblast growth factor 23 is a hormone that is
produced by the kidneys and decreases the circulating levels of 1,25 vitamin D, the
active form of vitamin D.
Q: What is the take-home message of the session?
A: Vitamin D deficiency should be recognized early on to prevent bony deformities
and growth delay in children. Once recognized, vitamin D repletion should be initiated
promptly. Prevention and early identification of vitamin D deficiency is critical
especially in high-risk populations like children of dark skin, children of malnourished
mothers, malnourished children and children who have limited exposure to sunlight.
Vitamin D deficiency also should be corrected in other diseases, including renal disease
and immunological disorders.