‘Feeding’ brain development: Key nutrients essential during first 1,000 days
Sarah JaneSchwarzenberg, M.D., FAAP
The brains of normal children develop in a complex process involving changes in the
number and organization of brain cells in a specified sequence. The most active period
of neurologic development occurs in the first 1,000 days of life. This period, beginning
at conception and ending at the start of the third postnatal year, is a time of tremendous
opportunity for neurodevelopment — and a time of great vulnerability.
In a new policy statement, the Academy emphasizes the importance of the nutritional
environment of the fetus, infant and toddler and the effect it has on whether brain
growth and differentiation proceed normally. The policy, Advocacy for Improving Nutrition in the First 1,000 Days to Support Childhood Development
and Adult Health from the Committee on Nutrition, is available at https://doi.org/10.1542/peds.2017-3716 and will be published in the February issue of Pediatrics.
Adequate overall nutrition (i.e., absence of malnutrition) and provision of adequate
amounts of key macro- and micronutrients at critical periods in development are necessary
for normal brain development. Importantly, the definition of “malnutrition” includes
both undernutrition (inadequate amounts of macro- and/or micronutrients) and obesity
(excessive calories, often at the expense of other crucial nutrients). Many nutrients
exhibit a U-shaped risk curve, whereby inadequate or excessive amounts place the individual
at risk, according to the policy. Both forms of malnutrition affect neurodevelopment,
and they may coexist in an individual.
The key nutrients studied thus far that support neurodevelopment include protein,
zinc, iron, choline, folate, iodine, long-chain polyunsaturated fatty acids and vitamins
A, D, B6 and B12.
Promoting healthy nutrition
The policy focuses on supporting pediatricians and other health care providers in
promoting healthy nutrition and advocating for the expansion of programs that affect
early life nutrition as a means of preventing early developmental loss. In this way,
the policy offers an opportunity to improve each child’s chance for the healthiest
and most productive life possible.
Pediatricians are encouraged to be knowledgeable about nutritional issues across the
first 1,000 days. For the fetus and newborn, this includes partnering with obstetricians
and family physicians to encourage improvements in maternal diet and attention to
clinical situations that may limit the fetus’s access to crucial micronutrients (e.g.,
maternal diabetes); educating pregnant women about breastfeeding; and supporting them
As the child becomes older, pediatricians can become conversant about food sources
that supply the critical nutrients necessary for brain development during particularly
important times. The AAP Pediatric Nutrition Handbook (Yellow Book), Bright Futures and the AAP breastfeeding recommendations (see resources)
provide guidance for pediatricians.
Families also need support to take advantage of programs that provide nourishing food,
particularly the Special Supplemental Nutrition Program for Women, Infants and Children
(WIC) after the first year of life.
Pediatricians and others who care for children are among the most powerful advocates
for preservation and extension of programs that provide food to pregnant women, nursing
mothers, infants and children. The information in the policy may provide evidence-based
support for advocacy at the local, state and federal levels.
It is crucial to oppose changes in eligibility or financing structures that would
adversely affect key programs offering early childhood nutrition. Such changes include
providing funding through block grants or unlinking nutrition and health assistance
programs, such as the adjunctive eligibility between WIC and Medicaid. Federal nutrition
programs like the Supplemental Nutrition Assistance Program (SNAP) are successful
because of eligibility rules and a funding structure that make benefits available
to children in almost all families with little income and few resources.
If deficiencies in key nutrients do occur during the first 1,000 days, pediatricians
can anticipate the need for early screening for neurodevelopmental concerns and intervention.
Finally, the policy seeks to empower pediatricians and other child health care providers
to support organizations that work to reduce hunger at the local level, in the United
States and globally — the “hunger community.” It is important to encourage creation
of food packages and meals that target the specific needs of pregnant women, breastfeeding
women and children in the first two years of life.
Educate pregnant women about breastfeeding and help mothers and their infants when
Advocate at the local, state and federal levels to preserve and strengthen nutrition
programs, focusing on maternal, fetal and neonatal nutrition.
Become conversant about food sources that supply the critical nutrients for brain
development during particularly important times.
Focus attention of existing programs on improving micro- and macronutrient offerings
for infants and young children.
Encourage families to take advantage of early childhood nutrition programs and advocate
for eliminating barriers to enrolling and remaining in such programs.
Dr. Schwarzenberg is a co-author of the policy and member of the AAP Committee on